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35 Cards in this Set

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Acetylcholinesterase Inhibitors

Organophosphates
S&S:
Diarrhea, Urination, Miosis, Bradycardia, Bronchostriction, Excitation (Muscle and CNS)
Lacrimation Salivation, Sweating
Intervention/ ANTIDOTE

: Respiratory support:
Atropine

2-Pam (pralidoxime)
irreversible AChE Inhibitors
Atropine and Muscarinic blockers
↑HR ↑ BP, Hyperthermia (hot dry skin) delirium, Hallucinations, Mydriasis
Intervention/ ANTIDOTE
Control CV symptoms and Hyperthermia+ Physostigmine (Cross BBB)
Carbon Monoxide Poisoning
>10% Carboxy Hb
Nausea, vominting dyspnea with Hyperventilation, Mydriasis, vertigo,
CV signs prominent ↓ BP, syncope ↑HR, arrhythmias
Intervention/ ANTIDOTE

Hyperbaric Oxygen and decontamination
Humidifed 100% O2 in mild overdose is ok
CNS Stimulants
Anxiety/agitation, Hyperthermia(warm sweaty skin) MYDRIASIS, ↑HR ↑BP, psychosis, seizure.
Intervention/ ANTIDOTE

Control CV and hyperthermia symptoms
Benzo for seizures
OPIODS Analgesic
Lehtargy, Sedation ↓ HR ↓ BP hypoventilation(resp depression)miosis, coma, respiratory failure
Intervention/ ANTIDOTE

Ventilatory support
Naloxone/natrexone frequent intervals
Salicylates (ASA)
Confusion Lethargy, Hyperventilation,
dehydration hypokalemia
Acidosis seizure coma
Intervention/ ANTIDOTE

Correct acidosis, and electrolytes--> urinary alkalinization possible hemodialysis
Sedative/ Hypnotics (BZDs)
ALCOHOL
Disinhibition, lethargy,ataxia, nystagmus,stupor, coma, hypothermia, respiratory failure
Intervention/ ANTIDOTE
ventalatory support
FLUMAZENIL if BZDs used

SSRI
agitation, curgusion, Hallucination, Muscle rigitidy
Hyperthermia↑HR ↑BP Siezures
Intervention/ ANTIDOTE

If neuroleptic syndrom use Dantrolene
COntrol Hyperthermia and seizures... possible cyproheptadine, antipsychotics
Tricyclic Antidepressants
Mydriasis, Hyperthermia (hot dry skin) 3C's : convulsions coma, cardiotoxicity) _-> arrhythmias
Control Seiszure and hyperthermia... correct Acidosis and possibly arrhythmia
Succinyl Choline
Currarine Drugs (tubocurarine)
halothane
MAlignant hyperthermia

Muscle rigidity hyperthermia hypertension, acidosis, hyperkalemia
Dantrolene Decrease skelatal muscle contractility by blocking Ca release from the sarcoplasmic reticulum
Arsenic
wood Presevative
S&S:
Acute: gastroenteritis, hypotension, metabolic acidosis, GARLIC BREATH,"ricewater" stool Torsades Seizures
Pallor- skin Pigmentation (rain Drop Pattern) allopecia, stocking glove neuropathy
Myelosupression
Intervention and Antidote
Dimercaprol - Acute
Penicillamine- Chronic
Copper
Wilson Disease:
Keiser Fleisher ring...
Penicillamine
Iron
Medicinal anemials Prenatal supplements
Acute; Mainly in kids
sever GI distress--> Necrotizing Gastroenteritis, with Hematemsis
bloody diarrhear, Dyspnea, shock, Coma
Gastric Lavage
DeFEROxamine IV

FEROUS--> IRON
Lead Poisoning
Tapwater, Lead paintchips, herbal, remedies, gas sniffing, glazed kichenware
Acute: Nausea and vomiting Gi distress pain, malaise, tremor, Tinnitus, Paraesthesias, encephalopathy (red or black feces)
Children: Succimer is the treatment
in adults ... Gastric lavage and Dimercaprol, or EDTA
Mercury
(elemental in instruments. Salts used as amalgum,
battaries, Fish, fireworks
electroplating
Acute vapor inhalation: C/P dyspnea, pneumonitis

Acute: Inorgani salt ingestion- Hemmorhagic gastroenteritis acute Tubular Necrosis Shock
Dimercaperol
or Succimer
Acetominophen
N-Acetylcystine
Precursor to glutathione
Salycilates (ASA)
Na+ HCO3- (alkalinize Urine) dialysis
Amphetamines (basic)
NH4 CL (acidify urine)
Organophosphates

Acetylcholinesterase inhibitors
Atropine & Pralidoxime (2-pam)
Anti-Muscarinic Anticholinergic
Physostimine Salycilate
Beta Blocker
Glucagon
Digoxin
stop Dig, Normalize potasium
Lidocain, Anti DIG-Fab
Mg2+
Iron
Deferoxamine
Mecury, Arsenic, Gold
Dimercaperol
Cynaide
Nitrites & thiosulfate (reducing agent
Methemoglobin
Methelyne BLUE

Alternative
Vitamin C
Carbon Monoxide
100% Hyperbaric O2
Methanol, Ethylen Glycol
Ethanol, dialasis, Fomepizole
Opiods
Naloxone (NARCAN)
/Naltrexone
Benzodiazapines
Flumezenil
(ROMAZICON)
TCAs
HCO3-
Plasma alkalinization
Heparin
Protamine
Warfarin (coumadin)
Vitamin K
Fresh Frozen Plazma
tPA, Streptokinase
Aminocaproic Acid
Theophyllin
Beta blocker
Esmolol