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12 Cards in this Set

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Clinical Cobb Syndrome
Synonym
Cutaneomeningospinal angiomatosis
Inheritance
Sporadic
Prenatal
None
Incidence
Rare; spinal arteriovenous malformations (AVMs) more common without skin involvement, M=F
Age at Presentation
Birth; neurologic complications develop in early adulthood
Pathogenesis
Unknown
Clinical
Skin
Posterior thoracic/lumbar/limb vascular lesion in a dermatornal distribution a corresponding segment of spinal cord

Central Nervous System
Fast flow vascular malformation within the intramedullary (most common) spinal cord with secondary compression/anoxia secondary pain, weakness, muscle atro¬phy, and sensation loss below the level of compression; bladder and sphincter disfunction if malformation extensive; subarachnoid hemorrhage; malformation rna. involve vertebral body
D/Dx
Capillary malformation overlying a meningoencephalocele, spinal dysraphism, tethered spinal cord
Lab
MRI, MRA
Spinal angiography
Management
Referral to neurologist complete neurologic examination Referral to neurosurgeon extirpation of lesion, embolization
Prognosis
Dependent on degree of symptomatology prior to intervention may be irreversible