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12 Cards in this Set

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Antihistamines

bind the histamine receptor and prevent binding of histamine




2nd generation are actively pumped out of CNS, less CNS adverse effects (drowsiness)




1st gen: diphenhydramine




2nd gen: loratidine, certizine

Bortezomib

inhibits Nfkb pathway by stabilizing the inhibitor protein Ikb

NSAID's

inhibit COX-1 and COX-2 that leads to decreased prostaglandin synthesis

Aspirin (acetylsalicylic acid)

irreversibly inhibits COX-1

Acetominophen

analgesic and antipyretic, but not an NSAID




Hepatotoxicity with overdose

Celecoxib

only COX-2 selective inhibitor

Zileuton

leukotriene synthesis inhibitor

Montelukast

leukotriene receptor antagonist

Omalizumab

Prevents binding of IgE to Mast cells




Used for hard to treat asthma

Roflumilast

inhibits PDE4 and causes accumulation of cAMP




anti-inflammatory by preventing activation and recruitment

TNF-alpha inhibitors

Etancercept




Infliximab




Adalimumab




Certolizumab pegol

Telcagepant

CGRP antagonist, used for migraine treatment




hepatic toxicity killed development